TFS – Communicable Diseases Research

Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells

Article

Published on 2022-11-012022-11-15
Journal: Acta pharmacologica Sinica
[Category] COVID19(2023년), SARS, 진단,

Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approaches

Article

Published on 2022-08-172022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 바이오마커, 치료기술, 치료제,

[키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets therapeutic targets. Vaccine Variability with COVID-19 YY1
[DOI] 10.3389/fimmu.2022.918692 PMC 바로가기

Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands

비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬

Comparative Study

Published on 2022-07-082022-09-11
Journal: BMC Genomics
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic
[DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study

Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells

Research

Published on 2022-03-172022-10-05
Journal: Nature Immunology
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘,

Outcome of SARS CoV-2 inpatients treated with convalescent plasma: One-year of data from the Veneto region (Italy) Registry

Randomized Controlled Trial

Published on 2022-03-012022-10-04
Journal: European journal of internal medicine
[Category] SARS, 임상,

[키워드] absence Administered Admission adverse event adverse events age anti-SARS-CoV-2 antibody Antibody titre Arterial hypertension Cancer cardiovascular disease CCP CCP administration CCP therapy chest CT scan chest X-ray Chronic kidney disease Comorbidity condition consolidation contribute convalescent convalescent plasma COVID-19 COVID-19 patient Data analysis death Deceased disease drug early treatment Elderly patient enrolled Factor Follow-up fraction Frequency greater hospital Hospitalization hospitalized patients Inclusion inclusion criteria Inpatient intensive care unit interstitial Italy life-threatening lung involvement mechanical ventilation Mortality Neutralizing neutralizing antibody objective Older age outcome overcome oxygen oxygen saturation Oxygen therapy PaO Patient patients treated patients with COVID-19 plasma Primary outcome Prognosis progression radiological randomized controlled study reduced registry respiratory rate SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection severe COVID-19 shown significantly tachypnea TFS therapeutic titre transfused treated Treatment Veneto Veneto region. were recorded
[DOI] 10.1016/j.ejim.2021.12.023 PMC 바로가기 [Article Type] Randomized Controlled Trial

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절

Research Article

Published on 2022-01-182022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence
[DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article

SBSA: an online service for somatic binding sequence annotation

SBSA: 체세포 결합 시퀀스 주석을 위한 온라인 서비스

Article

Published on 2022-01-112022-09-11
Journal: Nucleic Acids Research
[Category] 변종, 유전자 메커니즘,

Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico Analysis

Article

Published on 2021-11-292022-10-30
Journal: Non-Coding RNA
[Category] COVID-19,

Theaflavin Chemistry and Its Health Benefits

Review Article

Published on 2021-11-182022-10-29
Journal: Oxidative Medicine and Cellular Longevity
[Category] COVID-19,

Effects of Bacille Calmette Guerin (BCG) vaccination during COVID-19 infection

Research article

Published on 2021-11-012022-10-05
Journal: Computers in biology and medicine
[Category] SARS, 바이오마커, 변종,

[키워드] activities acute respiratory syndrome ADORA3 analysed Analysis analysis Bacille calmette guerin (BCG) BCG BCG vaccination caused CCL4 CCR2 CD33 Comorbidity condition contagious coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID‐19 Critical CXCL1 CXCL8 cytokine DEGs differentially expressed gene Differentially expressed genes driving drug candidate Drug molecules Effect elements enrichment analysis expression expression pattern finding functional functional enrichment analysis Gene ontology Genes Genetic IFNg IL-17 Infection Interaction investigated ITGB2 miRNA molecular mononuclear cell more difficult Mortality network analysis Novel coronavirus pandemic pathway Pathways PBMC Peripheral blood PPI PTGS2 Regulatory Research SARS-CoV-2 SARS-COV-2 infection severity significantly Spread TFS therapeutic TLR5 transcriptomic vaccination Vaccine virus spread
[DOI] 10.1016/j.compbiomed.2021.104891 [Article Type] Research article